Stafford McDowall skippers Scotland for the fixture after another impressive campaign in Glasgow colours, with George Horne named as vice-captain. The pair are joined in the starting XV by Rory Sutherland, Gregor Hiddleston, Max Williamson, Gregor Brown and Ollie Smith.
Saturday's match marks a milestone for Hiddleston, who makes his first Scotland start after debuting earlier this year, while Brown will wear the number eight jersey for the first time at international level.
On the bench, Seb Stephen is in line to make his Scotland debut after being named in a matchday 23 for the first time, with Zander Fagerson, Scott Cummings, Jamie Dobie and Sione Tuipulotu also selected to take Glasgow's representation to 12 players.
Scotland
15 Tom Jordan (Bristol Bears) (19)
14 Darcy Graham (Edinburgh Rugby) (56)
13 Ollie Smith (Glasgow Warriors) (12)
12 Stafford McDowall (Glasgow Warriors, Captain) (17)
11 Duhan van der Merwe (Edinburgh Rugby) (53)
10 Fergus Burke (Saracens) (4)
9 George Horne (Glasgow Warriors, Vice-Captain) (46)
1 Rory Sutherland (Glasgow Warriors) (50)
2 Gregor Hiddleston (Glasgow Warriors) (2)
3 D'arcy Rae (Edinburgh Rugby) (7)
4 Jonny Gray (USA Perpignan) (82)
5 Max Williamson (Glasgow Warriors) (14)
6 Josh Bayliss (Bath Rugby, Vice-Captain) (17)
7 Freddy Douglas (Edinburgh Rugby) (2)
8 Gregor Brown (Glasgow Warriors) (18)
Substitutes
16 Seb Stephen (Glasgow Warriors) (uncapped)
17 Pierre Schoeman (Edinburgh Rugby) (51)
18 Zander Fagerson (Glasgow Warriors) (83)
19 Scott Cummings (Glasgow Warriors) (51)
20 Magnus Bradbury (Edinburgh Rugby) (23)
21 Liam McConnell (Edinburgh Rugby) (1)
22 Jamie Dobie (Glasgow Warriors) (21)
23 Sione Tuipulotu (Glasgow Warriors) (40)