Connacht went down 21-18 to Cardiff at the weekend and will be looking to complete a Celtic League double over Glasgow, having won 30-19 in Hughenden earlier this season.
Six of the changes are up front with Bernard Jackman and Adrian Clarke returning to the front row, while Mike McCarthy partners Andrew Farley in the second row.
There is a new backrow formation with flankers Paul Neville and Tom Carter returning to the side, while John O'Sullivan is selected at No.8.
In the backs, Shane Moore starts at inside centre with top try scorer Conor McPhillips returning on the left wing.
M McHugh, M Mostyn, D Yapp, S Moore, C McPhillips, E Elwood, C O'Loughlin, D McFarland, B Jackman, A Clarke, M McCarthy, A Farley, P Neville, T Carter, O'Sullivan
Replacements: J Fogarty, F Boiroux, D Browne, M Swift, M Walls, D Hewitt, T Robinson