Cammy Mather is back at blindside flanker with Gordon Bulloch at hooker, Andy Henderson at centre, and Dan Parks at fly-half.
Glasgow's Andy Hall and Graeme Beveridge are among the replacements.
No caps will be awarded for Saturday's game.
Glasgow players not involved in Saturday's match are part of the advanced party leaving today for Scotland's summer tour of Australasia.
Scotland
15 Chris Paterson (Edinburgh Rugby)
14 Simon Danielli (Bath Rugby)
13 Tom Philip (Edinburgh Rugby)
12 Andrew Henderson (Glasgow Warriors)
11 Simon Webster (Edinburgh Rugby)
10 Dan Parks (Glasgow Warriors)
9 Chris Cusiter (The Borders)
1 Allan Jacobsen (Edinburgh Rugby)
2 Gordon Bulloch (Glasgow Warriors)
3 Bruce Douglas (The Borders)
4 Iain Fullarton (Sale Sharks)
5 Scott Murray (Edinburgh Rugby) CAPTAIN
6 Cameron Mather (Glasgow Warriors)
8 Allister Hogg (Edinburgh Rugby)
7 Scott Gray (Bath Rugby)
Substitutes
16 Steve Scott (The Borders)
17 Joel Brannigan (Edinburgh Rugby)
18 Scott MacLeod (The Borders)
19 Andrew Hall (Glasgow Warriors)
20 Graeme Beveridge (Glasgow Warriors)
21 Stephen Cranston (The Borders)
22 Gareth Morton (The Borders)