The pair are both rewarded for their impressive form during pre-season with places in the starting XV, as the Warriors prepare to kick off their 2025/26 BKT United Rugby Championship campaign.
Johnny Matthews packs down between Jamie Bhatti and Fin Richardson in the front-row, the hooker having crossed for a memorable bonus-point-securing try in the club's last meeting with the squad from Durban.
Jare Oguntibeju partners Alex Samuel in the second row, having started together in the pre-season victory over Northampton Saints a fortnight ago.
Jack Dempsey will make his first competitive appearance for the club since January after recovering from an injury sustained on Scotland duty during the Guinness Six Nations, as he combines with Matt Fagerson and Rory Darge in an all-international back-row.
Lancaster is handed the number 10 shirt after his summer arrival from Racing 92, lining up outside George Horne in the half-backs.
Stafford McDowall captains the side from outside centre, the skipper partnering Yule in a powerful midfield combination.
Josh McKay starts at full-back, with Kyle Rowe and Ollie Smith on the wings.
A six-two split of forwards and backs on the bench sees a trio of British & Irish Lions ready to make an impact, as Scott Cummings, Rory Sutherland and Gregor Brown all take their places amongst the replacements.
Gregor Hiddleston and Sam Talakai join Sutherland as the front-row cover, whilst Euan Ferrie wears the number 21 jersey.
The backline is covered by Jamie Dobie and Adam Hastings, with both men having been prominent on Scotlan's summer tour.
Speaking following selection, Head Coach Smith told glasgowwarriors.org: "Playing at Scotstoun is always a privilege and we are looking forward to starting a new campaign at home in front of our home supporters.
"We know that home support will be vital and we know that the Warrior Nation will be make themselves heard tomorrow night.
"Even without their South African internationals, the Sharks are proof that there are no underpowered teams in the BKT URC - their squad is built to perform and their depth was a key factor in them finishing in the top four last season."
15 Josh McKay (64)
14 Kyle Rowe (37)
13 Stafford McDowall (Captain) (94)
12 Kerr Yule (0)
11 Ollie Smith (45)
10 Dan Lancaster (0)
9 George Horne (139)
1 Jamie Bhatti (126)
2 Johnny Matthews (97)
3 Fin Richardson (8)
4 Jare Oguntibeju (9)
5 Alex Samuel (40)
6 Matt Fagerson (125)
7 Rory Darge (67)
8 Jack Dempsey (55)
Substitutes
16 Gregor Hiddleston (27)
17 Rory Sutherland (12)
18 Sam Talakai (21)
19 Scott Cummings (142)
20 Gregor Brown (35)
21 Euan Ferrie (39)
22 Jamie Dobie (88)
23 Adam Hastings (70)
Match Officials
Referee: Craig Evans (WRU, 68th league game)
AR 1: Ru Campbell (SRU) AR 2: Rob McDowell (SRU)
TMO: Keith David (WRU)