Returning after injury is flanker Jason White, which sees the back-row recast with Simon Taylor moving to No 8 and Allister Hogg switching to openside flanker. Glasgow's Jon Petrie drops to the bench.
Second-half substitutes from last weekend, stand-off Gordon Ross, lock Nathan Hines and scrum-half Mike Blair will all start this time round.
Chris Cusiter was ruled out of selection on account of the Achilles injury he suffered against Wales, so Glasgow's Graeme Beveridge is called onto the bench where he is joined by Stuart Grimes and Dan Parks who all started against Wales.
Scotland
15 Chris Paterson (Edinburgh Rugby)
14 Rory Lamont (Glasgow Warriors)
13 Andy Craig (Glasgow Warriors)
12 Hugo Southwell (Edinburgh Rugby)
11 Sean Lamont (Glasgow Warriors)
10 Gordon Ross (Leeds Tykes)
9 Mike Blair (Edinburgh Rugby)*
1 Tom Smith (Northampton Saints)
2 Gordon Bulloch (Glasgow Warriors) CAPTAIN
3 Gavin Kerr (Leeds Tykes)
4 Nathan Hines (Edinburgh Rugby)
5 Scott Murray (Edinburgh Rugby)
6 Jason White (Sale Sharks)
8 Simon Taylor (Edinburgh Rugby)
7 Allister Hogg (Edinburgh Rugby)*
Substitutes
16 Robbie Russell (London Irish)
17 Bruce Douglas (The Borders)
18 Stuart Grimes (Newcastle Falcons)
19 Jon Petrie (Glasgow Warriors)
20 Graeme Beveridge (Glasgow Warriors)
21 Dan Parks (Glasgow Warriors)
22 Andrew Henderson (Glasgow Warriors)
Travelling with the squad: 23 Jon Dunbar (Leeds Tykes) 24 Ben MacDougall (Edinburgh Rugby)
Referee: Alain Rolland (Ireland). Touch-judges: Mark Lawrence (South Africa) and Nigel Whitehouse (Wales). Television match official: Christophe Berdos (France)
* = Member of Scottish Institute of Sport