Adam Byrnes will make his competitive debut for Leinster while John Lyne and Jamie Heaslip, in for the injured Eric Miller, are also named in the pack.
Guy Easterby will partner Christian Warner at half-back with Kieran Lewis at centre alongside Felipe Contepomi.
Gary Brown claims a wing berth with Brendan Burke dropping to the bench.
Leinster: G Dempsey, G Brown, K Lewis, F Contepomi, R Kearney, C Warner, G Easterby, J Lyne, B Jackman, W Green, A Byrnes, B Gissing, C Potts, K Gleeson, J Heaslip.
Replacements: E Byrne, D Blaney, S Crawford, N Ronan, B O'Meara, E Hickey, B Burke.