With skipper Barry Williams and prop Paul James announced as the ninth and 10th Opsreys players to undergo surgery this season, the region has suffered something of a personnel crisis.
On top of that they are without their Wales squad players Shane Williams, Duncan and Adam Jones, and Jonathan Thomas, who picked up a hamstring injury against Stade Français last week.
Included in their 22-man squad are semi-pros Craig Mitchell and Martin Roberts from Neath, and Swansea duo Richard Hibbard and Alun Wyn Bevan.
Ospreys: (from) S Terblanche, D Karauna, A Cashmore, S Parker, R Mustoe, A Bishop, M Jones, S Connor, J Spice, M Roberts; C Griffiths, C Mitchell, A Millward, H Bennett, R Hibbard, A Newman, A Wyn Jones, L Bateman, D Dillon, L Beach, S Tandy, J Bater