The 24-year-old will replace Dougie Hall at hooker for the match at the Millennium Stadium.
But, while Scott, who has earned five caps for his country including a substitute appearance against Les Bleus, was disappointed at missing out last weekend, he is relishing the chance to prove himself as the Scotland boss utilises his squad.
Scott said: "I thought it would be very hard to change a winning team. So I was delighted to get selected and I'm looking forward to Sunday now.
"I certainly wasn't expecting it. Since I have been involved though, I have learned to expect anything. It must have been hard for the coaches but I'm delighted to be involved this week.
"Frank has always said the squad is there for competition for places, which can only be good. It bodes well for the whole tournament that we have those selection 'problems', especially in the hooker position. There are three guys Frank thinks can perform in the Six Nations and we will try to put in the best display we can.
Scott believes it's his own ambition and drive that have got him to this stage.
"I was never tagged as a prospect early on, but I was always willing to put in as much work as I could," he said.
"I remember travelling every day from Biggar to Melrose and then making the leap from club rugby into professionalism before there were academies or the involvement in the Institute of Sport.
"That's great that it exists now, to help guys coming through make the change, but I feel that because it wasn't there for me I've had to earn everything that I've achieved."
Regarded as the best lineout thrower of the three hookers, Scott aims to give Scotland an advantage in that area this weekend.
"Our line-out didn't function as well as it could have done at the weekend. It is definitely a strength for us. There were a few mistakes on Sunday and, hopefully, we will fix it this week.
"It is hard because there is a lot of movement and our driving maul from the line-out was really good against France.
"The best way to achieve that is a full-man line-out but, obviously, by doing that, it gives the opposition more chances to compete."
Scott isn't averse to being involved in a rolling maul himself, even when backs like Sean Lamont get themselves involved, as in Sunday’s second try.
"I don’t know how Sean managed to worm his way in but if I'd been there, he would have been back out again sharpish," he joked.
"It's all part of our ploy, if we get one going forward like that, then Sean and Andy Henderson can come in. They're two of the most physical players in the team so why not?"
On the field against France as Scotland ground down the game, Scott accurately threw to two key lineouts at the death, which allowed the Scots to keep possession and deny France a comeback.
"That was mostly from Gordon Ross," he explained.
"He came into the huddle and said that he didn't want to see the ball for the remaining six minutes, and with experienced guys like Scott Murray and Jon Petrie in the pack we knew what to do.
"Just to be part of it on Sunday was magnificent, the buzz was fantastic."