Glasgow's Donnie Macfadyen, Dan Parks, Scott Lawson and Andy Henderson start for Scotland.
On Donnie's inclusion Frank Hadden said: "Donnie did well when he came on last week. He is an experienced international player and we believe he is the man for the occasion on Saturday."
Jon Petrie and Sam Pinder are named among a group of eight players that will be trimmed to seven to form Scotland's bench options.
Scotland team to play South Africa at the ABSA Stadium, Durban on Saturday 10 June (ko 3.00pm SA time)
15 Hugo Southwell (Edinburgh Gunners)
14 Chris Paterson (Edinburgh Gunners)
13 Marcus Di Rollo (Edinburgh Gunners)
12 Andrew Henderson (Glasgow Warriors)
11 Sean Lamont (Northampton Saints)
10 Dan Parks (Glasgow Warriors)
9 Mike Blair (Edinburgh Gunners)*
1 Gavin Kerr (Leeds Tykes)
2 Scott Lawson (Glasgow Warriors)*
3 Bruce Douglas (Border Reivers)
4 Nathan Hines (Perpignan)
5 Scott Murray (Edinburgh Gunners)
6 Jason White (Sale Sharks) CAPTAIN
8 Allister Hogg (Edinburgh Gunners)*
7 Donnie Macfadyen (Glasgow Warriors)
Subs from
Dougie Hall (Edinburgh Gunners)
Craig Smith (Edinburgh Gunners)
Alastair Kellock (Edinburgh Gunners)*
Jon Petrie (Glasgow Warriors)
Kelly Brown (Border Reivers)*
Sam Pinder (Glasgow Warriors)
Gordon Ross (Leeds Tykes)
Simon Webster (Edinburgh Gunners)
* = Member of Scottish Institute of Sport
Referee: Donal Courtney (Ireland).
Touch-judges: Joel Jutge (France) and Rob Debney (England).
TMO: Simon McDowell (Ireland)