The Warriors are back at strength as Scotland internationals Rory Lamont and Euan Murray return to action.
Coach Sean Lineen has made three changes to the starting side that lost 13-3 away to the Newport Gwent Dragons at the beginning of this month as Lamont replaces Sean Marsden at fullback, Justin Va'a returns at loose-head for Kevin Tkachuk and Murray comes in at tight-head for Moray Low.
In addition, Tkachuk drops to the bench where he is joined by Scott Lawson to replace Ben Prescott and Eric Milligan respectively while Colin Shaw takes the No 22 position previously held by Scott Barrow.
Lineen said: "This match presents a real challenge for us but one that we've been waiting for. Saracens are a quality outfit and play and exciting brand of rugby. We've had two close games against them so far and on our day we can take this match.
"It's great to see Rory and Euan back in the starting line up. I know they will be keen to play well for their team mates and the Glasgow Warriors," he added.
15 Rory Lamont
14 Hefin O'Hare
13 Graeme Morrison
12 Andrew Henderson
11 Thom Evans
10 Dan Parks
9 Graeme Beveridge
1 Justin Va'a
2 Fergus Thomson*
3 Euan Murray*
4 Andy Newman
5 Alastair Kellock* CAPTAIN
6 Steve Swindall
7 John Barclay*
8 John Beattie*
Substitutes
16 Scott Lawson*
17 Kevin Tkachuk
18 Dan Turner
19 Andrew Wilson*
20 Donnie Macfadyen
21 Colin Gregor
22 Colin Shaw
* indicates member of the Scottish Institute of Sport
Not available due to injury – Jon Petrie, Francisco Leonelli (both groin), Sam Pinder and Allan Kelly (both shoulder injuries). Sam will be out for the remainder of the season following an operation to repair damage to his left shoulder.
Willie Brown (West of Scotland Institute of Sport) is the only National Academy players in club rugby action this week as he lines up at home for Hillhead-Jordanhill against Stirling County in previously postponed Premier Two fixture.