Glasgow's Richie Gray and Richie Vernon make their first starts for Scotland and are joined in the pack by John Barclay.
Max Evans and Graeme Morrison are in the centre while a sixth Warrior, the uncapped Ruaridh Jackson, is on the bench.
Scotland
15 Hugo Southwell (Stade Français)
14 Rory Lamont (Toulon)
13 Max Evans (Glasgow Warriors)
12 Graeme Morrison (Glasgow Warriors)
11 Sean Lamont (Scarlets)
10 Dan Parks (Cardiff Blues)
9 Mike Blair (Edinburgh) CAPTAIN
1 Allan Jacobsen (Edinburgh)
2 Ross Ford (Edinburgh)
3 Euan Murray (Northampton Saints)
4 Richie Gray (Glasgow Warriors)
5 Jim Hamilton (Gloucester)
6 Kelly Brown (Saracens)
8 Richie Vernon (Glasgow Warriors)
7 John Barclay (Glasgow Warriors)
Substitutes
16 Scott Lawson (Gloucester)
17 Alasdair Dickinson (Gloucester)
18 Nathan Hines (Leinster)
19 Ross Rennie (Edinburgh)
20 Rory Lawson (Gloucester)
21 Ruaridh Jackson (Glasgow Warriors)
22 Nikki Walker (Ospreys)