It will be Scotland U20's first outing since lifting the World Rugby U20 Trophy in Edinburgh last summer, with Murray's outfit welcoming Italy to Hive Stadium in round one.
Ventisei forms part of an all-Glasgow centre partnership for the home side, linking up with Kerr Yule in the midfield for Friday's clash.
Fergus Watson starts on the wing, with the Biggar RFC product joining Matthew Urwin in the back-line.
Joe Roberts is selected at hooker after being named in a senior Glasgow Warriors matchday 23 for the first time in Sunday's win over Connacht, with club-mate Ollie McKenna starting alongside the Aberdonian in the front-row.
Dan Halkon starts in the engine room after impressing for Glasgow Warriors A to date in 2024/25, as Jake Shearer rounds out the Glasgow cohort after being selected amongst the replacements.
Scotland U20 team to play Italy U20 on Friday at Hive Stadium (ko 7.15pm) - live on BBC iPlayer
15 Jack Brown - Edinburgh Rugby
14 Guy Rogers - University of Surrey/Harlequins
13 Johnny Ventisei - Captain - Glasgow Warriors
12 Kerr Yule - Glasgow Warriors
11 Fergus Watson - Glasgow Warriors
10 Matthew Urwin - Glasgow Warriors
9 Noah Cowan - Brunel University/Ealing Trailfinders
1 Ollie McKenna - Glasgow Warriors
2 Joe Roberts - Glasgow Warriors
3 Ollie Blyth-Lafferty - Edinburgh Rugby
4 Charlie Moss - Montpellier
5 Dan Halkon - Glasgow Warriors
6 Christian Lindsay - Loretto School/Edinburgh Rugby
7 Billy Allen - Dungannon RFC
8 Reuben Logan - Northampton Saints
Substitutes
16 Seb Stephen - Edinburgh Academical FC
17 Jake Shearer - Glasgow Warriors
18 Ryan Whitefield - Biggar RFC
19 Bart Godsell - Loughborough University
20 Oliver Duncan - Edinburgh Rugby
21 Hector Patterson - Edinburgh Rugby
22 Ross Wolfenden - Edinburgh Rugby
23 Nairn Moncrieff - Edinburgh Rugby