Kyle Steyn is expected to miss a number of upcoming matches, including the Champions Cup last-16 clash with the Bulls, after returning from international duty with a foot stress fracture.
Jamie Dobie is unlikely to feature again this season after shoulder surgery, while Gregor Brown is expected to be out until at least June with a hamstring injury. Scott Cummings is also facing four to six weeks on the sidelines.
Off the field, the club has also been dealt a blow with Jack Dempsey set to leave at the end of the season for a lucrative move to Japan. Head Coach Franco Smith admitted finances played a key role in the decision:
"We love Jack and I'm really proud of him, but when people play well, somebody else with a bigger chequebook comes along,"
"It's happened my whole coaching career and I've learned how to deal with it from a personal aspect.
"We're super proud that we had shares in Jack's future and obviously in his inheritance. It happens basically because he doesn't go there necessarily for the rugby side of things - that goes without saying too much.
"But he's contributed a lot here, he's an excellent player for us and he's done so well for Scotland. We couldn't stand in his way with the offer that he received. It was too big for us to match and that is the primary reason."
Looking ahead, Smith confirmed Glasgow are working on strengthening the squad, with new signings expected.
"We still have to balance the squad out for next season," said Smith.
"What I can say is that in the broader picture, we would like to maintain the quality of the programme we have. The players that we're going to bring in are going to be there to sustain that.
"I believe, like I said from the start, coaching beats the budget. We will try and keep on working hard with the quality of the people that we have."