Ryan Grant went over for two tries

Glasgow secured a try bonus-point but sustained a blow when stand-off Duncan Weir was carried off on a stretcher with what looked like a bad knee injury.

The Warriors ran in first-half tries through prop Ryan Grant (two) and winger Sean Maitland before scrum half Nikola Matawalu grabbed the fourth in the second half and DTH van der Merwe finished off the job with a counter to close the game.

Weir succeeded with two conversions and a penalty plus Peter Horne goaled a penalty.

Glasgow made a bright start fired up by scrum half Matawalu but twice stand-off Weir missed with kickable penalty attempts from the same spot to the left of the posts. In between Dan Biggar slipped his penalty attempt over.

Glasgow's disappointment was compounded after 10 minutes. John Barclay, in perhaps his final home game for Glasgow, appeared to touch down under the posts after good work by Maitland and Alex Dunbar, but the TV official decided the ball was held up.

But from the scrum five pressure Ryan Grant touched down by a post and Weir converted.

Ospreys had to make a change when hooker Richard Hibbard went off with a knee injury to be replaced by Scott Baldwin.

Glasgow's video luck changed after 17 minutes when Maitland's full speed chase to Matawalu's kick was confirmed as he touched down just within the sideline.

Weir failed to convert and after a long spell of Ospreys' phase play that came to nothing he suffered his third penalty miss.

Eight minutes from the break Glasgow scored their third try, an exciting one with the high-speed deft offloading begun by Matawalu finished off by Grant.

This time, from wide, Weir converted and his 40th-minute penalty sent Glasgow in with a deserved 22-3 lead.

Almost from the restart Ospreys' Adam Jones and Glasgow's Grant found themselves in the sin bin.

Replacement prop Cai Griffiths was no sooner on the field for Ospreys than he was plunging over by the posts with Biggar's conversion pulling back the score to 22-10.

In typical live-wire fashion Matawalu grabbed Glasgow's bonus point try after 57 minutes, taking a tap penalty to himself and shooting over from 20 metres before Ospreys awoke.

Weir again missed with his kick and soon a nasty injury saw him leave the pitch.

With Glasgow seeming unfocused when play restarted Ospreys replacement Sam Lewis got over with Biggar converting.

However Glasgow got back on track and finished the game in great style with a final minute try from DTH van der Merwe added to an earlier penalty by Peter Horne.

To wrap up the regular season Glasgow visit Connacht in a fortnight's time while Ospreys are now struggling for a top-four place and face a difficult trip to Leinster.