Paul and Cammy visited the children at the hospital along with rugby legend John Beattie to pledge £50,000 to the appeal by rugby charity Wooden Spoon.
"This a fantastic boost to the appeal and we would like to thank the Wooden Spoon for their generosity," says Shona Cardle, executive director of Yorkhill Children's Foundation.
"It's very exciting to become involved with an organisation like Wooden Spoon who will raise the money for our appeal at their annual ball on March 18.
"This £50,000 will help us take a step closer to reaching our magic million."
During their visit, the players and John - a former Scotland rugby internationalist and British Lion and now a BBC sports presenter - spent time chatting to young patients and signing lots of autographs.
Paul and Cammy also gave away the team shirts off their own backs! They were visibly moved and praised the children for their bravery.
"We really enjoyed our visit and it was a real pleasure to meet the youngsters," said Cammy.
Wooden Spoon is rugby's charity which has supported 250,000 disadvantaged children and young people throughout the UK.
In Scotland, they raise more than £100,000 each year for local projects with committees in Edinburgh, Aberdeen and Glasgow. Rugby stars Peter Brown and Gavin Hastings are joint honorary presidents.
All money raised in Scotland is spent locally and every pound raised is matched by the spoon national committee.
Recent major donations have included £60,000 for an A&E play area in the Royal Aberdeen Children's Hospital, a new residential facility for Capability Scotland at Stanmore House, Lanarkshire for which they donated £40,000 and £250,000 has been given towards the new care and residential school at Struan House, Tillicoultry for the Scottish Society for Autism.
Around 700 people will attend Wooden Spoon's glittering charity dinner at the Hilton hotel in Glasgow.
It's their main fundraising event in the west of Scotland and will be hosted by John Beattie.
Professor David Purdie and Wilson Hunter are the after-dinner speakers.
"Spoon is delighted to be able to contribute to the Magic Million Appeal to help very needy children at Yorkhill," says David Young, chairman of Wooden Spoon Glasgow.
The society was formed by a group of rugby fans, after England's five nations season ended in defeat in March 1983.
A group of English supporters were presented with a wooden spoon by their Irish compatriots to mark the occasion.
When they returned home, a proposal to play golf for the spoon attracted the interest of fellow rugby fans and 127 people attended a golf day at Farnham which raised £8450. The funds were cashed in for a minibus purchased for a special needs school in Aylesbury.
Anyone wishing to host a table at the Hilton dinner should contact David Young or Una Ross at The Wooden Spoon Society, Tel: 0141 226 3030.