Cammy Mather, Glasgows captain, is ruled out with the shoulder/chest injury that kept him out of the Scotland team against Ireland.
Sam Pinder misses out due to the ankle injury that forced him off at half-time in last Friday's match with Munster.
has returned from Sotuth Africa and Graeme Beveridge, David Millard and Andy Hall return to the Glasgow XV.
Mark McMillan returns to the squad after recovering from the ankle injury that caused him to miss last Friday's under-21 international against the Irish.
Jon Petrie will skipper Glasgow.
Glasgow
15 Glenn Metcalfe
14 David Millard
13 Graeme Morrison
12 Andrew Henderson
11 Sean Lamont
10 Dan Parks
9 Graeme Beveridge
1 Andrew Kelly
2 Gordon Bulloch
3 Euan Murray
4 Andy Hall
5 Nathan Ross
6 Roland Reid
8 Jon Petrie (captain)
7 Donnie Macfadyen
Replacements
16 Scott Lawson
17 Matt Proudfoot
18 Joe Beardshaw
19 Rory McKay
20 Mark McMillan
21 Calvin Howarth
22 Gareth Maclure