David Wallace replaces Denis Leamy at openside while Tom Bowman and Trevor Hogan come in for injured locks Paul O'Connell and Donnacha O'Callaghan.
In the threequarters Shaun Payne takes over from John Kelly on the right wing while James Story replaces the injured Rob Henderson.
Munster are able to parade 12 Test players in their side with three others on the bench.
Munster: C Cullen: S Payne, M Mullins, J Storey, A Horgan; R O'Gara, P Stringer; M Horan, F Sheahan, J Hayes, T Bowman, T Hogan, A QUinlan, D Wallace, A Foley.
Replacements: J Kelly, P Burke, E Reddan, S Keogh, D Leamy, G McIlwham, G Flannery.