BBC Sport has learned that the 23-year-old will line up along with older brother Sean on the wings for Matt Williams' side.
The elder Lamont has been one of Scotland's best performers in the three tournament matches so far.
Former Australian rugby league centre Ben MacDougall is likely to start on the bench.
Rory Lamont, a product of Northampton Saints' academy, joined Glasgow, where Sean also plays, in September.
Simon Danielli and Simon Webster are the men who have featured on the wing opposite Lamont in the three previous Six Nations matches.
Gordon and Alan Bulloch, and John and Martin Leslie, are the most recent siblings to play in the dark blue of Scotland.
But perhaps the most famous brother pairing, is Gavin and Scott Hastings, who helped Scotland win the Grand Slam in 1990.