The 29-year-old Ireland international has only just returned to first-team action after fracturing his right fibula in training last October, but he has been selected on the left wing for the province's penultimate game in the pool stages.
Hickie's return means there is no place in the starting XV for Kieran Lewis, who drops to the bench, where he will sit alongside the fit-again Rob Kearney.
Girvan Dempsey will make his 100th Leinster appearance
Meanwhile, the pack shows several changes to the one that faced the Llanelli Scarlets last weekend.
Emmet Byrne starts at tighthead prop in the absence of Will Green, who misses out with a collarbone injury, while Bryce Williams gets the nod as Malcolm O'Kelly's partner in the second row ahead of Adam Byrnes.
Finally, Eric Miller has been replaced at blindside flanker in favour of Cameron Jowitt.
Brian O'Driscoll will once again captain the province.
Leinster: Girvan Dempsey; Shane Horgan, Brian O'Driscoll, Gordon D'Arcy, Denis Hickie; Felipe Contepomi, Guy Easterby; Reggie Corrigan, Brian Blaney, Emmett Byrne; Bryce Williams, Malcolm O'Kelly; Cameron Jowitt, Keith Gleeson, Jamie Heaslip.
Replacements: David Blaney, Ronan McCormack, Adam Byrnes, Eric Miller, Brian O'Riordan, Kieran Lewis, Rob Kearney.