Scrum-half Chris Cusiter and forwards Scott MacLeod and Ross Ford are all included in the starting XV.
Stand-off Gregor Townsend will also return for the visitors after injury and Semo Sititi takes the place of Andy Rennick at number eight.
Borders head coach Steve Bates said: "We are very fortunate to welcome back Ross, Scott and Chris.
"Obviously Bruce Douglas has played a big part in the Six Nations so far, so he is having a rest, which is pretty sensible.
"With two of the local sides competing against each other, both with international players back from the Six Nations, will hopefully encourage people to come along and continue to support Scottish rugby."
Border Reivers
15 Moffat">Stuart Moffat; 14 Simon Danielli, 13 Ben MacDougall, 12 Calum MacRae, 11 Nikki Walker; 10 Gregor Townsend, 9 Chris Cusiter; 1 Paul Thomson (CAPTAIN), 2 Ross Ford, 3 Geoff Cross; 4 Scott MacLeod, 5 Opeta Palepoi; 6 Kelly Brown, 7 Andy Miller, 8 Semo Sititi
Substitutes: 16 Steve Scott, 17 Tom McGee, 18 John Dalziel, 19 Scott Gray, 20 Brendan McKerchar, 21 James King, 22 Charlie Hore