Graeme Morrison, Rory Lamont, Fergus Thomson and Craig Hamilton start, while Andy Wilson and Colin Gregor are on the bench.
Former Glasgow favourite Andy Hall, now with the Dragons is also on the bench for the game in Toronto.
The Churchill Cup aims to develop rugby in North America and this is the fourth competition in its history. The tournament has expanded this year from four countries to six to include A teams from both Scotland and Ireland.
Looking forward to taking on the current holders of the Churchill Cup title, England A, head coach Steve Bates said: "The players have integrated well since arriving in Canada and are really looking forward to playing against England who are very strong at this level.
"We have trained well and the guys are all aware of the opportunity that this tournament presents to them looking ahead to next year's World Cup."
Scotland A team to play England A in the Churchill Cup at York University, Toronto on Saturday 3 June (kick-off 2:45pm local time, 7:45pm BST)
15 Calum MacRae (Border Reivers) *
14 Simon Danielli (Border Reivers)
13 Graeme Morrison (Glasgow Warriors)
12 Matt Dey (Edinburgh Gunners)
11 Rory Lamont (Glasgow Warriors)
10 Phil Godman (Edinburgh Gunners)
9 Rory Lawson (Edinburgh Gunners) CAPTAIN *
1 Allan Jacobsen (Edinburgh Gunners)
2 Fergus Thomson* (Glasgow Warriors)
3 Colin Noon (Biarritz)
4 Craig Hamilton (Glasgow Warriors)
5 Mark Rennie (Lyon)
6 Ross Beattie (Northampton Saints)
7 Alasdair Strokosch (Edinburgh Gunners) *
8 David Callam (Edinburgh Gunners) *
Substitutes
16 A Kelly (Edinburgh Gunners) *
17 Alasdair Dickinson (Edinburgh Gunners) *
18 Andrew Wilson (Glasgow Warriors) *
19 Andy Hall (Newport-Gwent Dragons)
20 Scott Gray (Border Reivers)
21 Colin Gregor (Glasgow Warriors)
22 Nikki Walker (Border Reivers)
* = Denotes member of Scottish Institute of Sport
Officials
Referee: Gary Wise (New Zealand)
Touch judge 1: Olan Trevor (Ireland)
Touch judge 2: Kevin McCaslin (USA)
Fourth official: Gerry Clayton (Canada)
Fifth official: Derek Stoltz (Canada)