The Warriors can claim a historic quarter-final berth with a win over the English side at Hughenden, where the game starts at 7.30pm.
Rory Lamont moves to full-back in place of Sean Marsden from the side which defeated GRAN Parma last weekend.
Hefin O'Hare replaces Lamont on the wing with Colin Gregor and Andrew Henderson returning to the starting XV.
At scrum-half, Graeme Beveridge is restored to the team to replace Sam Pinder, who starts on the bench.
Lineen makes just one change to the Glasgow pack with prop Justin Va'a returning to the front row in place of Kevin Tkachuk, who moves to the bench.
Glasgow Warriors team to face Saracens in the European Challenge Cup at Hughenden on Friday 19 January (ko 7.30pm):
15 Rory Lamont
14 Hefin O'Hare
13 Colin Gregor
12 Andrew Henderson
11 Thom Evans
10 Dan Parks
9 Graeme Beveridge
1 Justin Va'a
2 Fergus Thomson
3 Euan Murray
4 Andy Newman
5 Alastair Kellock (CAPTAIN)
6 Steve Swindall
7 John Barclay
8 John Beattie
Replacements:
16 Eric Milligan
17 Kevin Tkachuk
18 Dan Turner
19 Andrew Wilson
20 Jon Petrie
21 Sam Pinder
22 Colin Shaw
Unavailable for selection due to illness/injury:
Willie Brown** (jaw), Scott Lawson* (foot), Francisco Leonelli (hip/groin), Moray Low** (head), Donnie Macfadyen (knee), Graeme Morrison (groin), Mike Roberts (jaw).
*Member of the Scottish Institute of Sport. ** Member of the West of Scotland Institute of Sport.