Flanker Robert Harley, who has impressed off the bench in recent weeks, will get his first start of the season when he runs out the Firhill tunnel alongside captain John Barclay.
On the young prospect, Sean said: "Robert is being rewarded for all his hard work. He's got a fantastic attitude and has made a big impact every time he's come on."
Although the Warriors haven't lost at home to an Irish side since Ulster on 17 April 2009, they will face a Connacht side that are coming into the encounter off the back of two straight wins.
Speaking about tomorrow night's opposition, Sean continued: "Tomorrow night will be a huge physical test.
"Connacht are coming into the game with some momentum, so we know we're going to have to really front up."
14 DTH van der Merwe
13 Max Evans
12 Graeme Morrison
11 Hefin O'Hare
10 Ruaridh Jackson
9 Colin Gregor
1 Jon Welsh
2 Fergus Thomson
3 Ed Kalman
4 Tom Ryder
5 Richie Gray
6 Robert Harley
7 John Barclay CAPTAIN
8 Richie Vernon
Substitutes
16 Pat MacArthur
17 Kevin Tkachuk
18 Moray Low
19 Aly Muldowney
20 Calum Forrester
21 Henry Pyrgos
22 Duncan Weir
23 Peter Murchie