George Hunter, Nick Campbell, Finn Russell and Murray McConnell are in the Ayr squad that will entertain Gala at Millbrae.
Sean Kennedy and Adam Ashe travel with Stirling County to take on Edinburgh Accies at Raeburn Place.
Finlay Gillies is among Aberdeen replacements for their home fixture against a Currie squad that includes Jonny Gray.
Fraser Thomson is at full-back in the Melrose team heading to Goldenacre to take on Heriot's.