"It's where you want to be as a professional rugby player," he said.
"You're playing the champions, it's the last home game of the season - the last game for a few players who might not be here next season - and you know if you win the game you're in the play-offs.
"And an extra little bit of motivation, our last game we didn't play well at all so we've got a lot of things to put into this 80 minutes."
Gregor also warned against repeating the mistakes of their last Pro12 outing, a 29-6 defeat by Scarlets .
"We just didn't turn up, " he said.
"Maybe we had a different mental approach going into the game, but we weren't at our best.
"But there's always learning when you play, and sometime defeats are more important than victories.
"The fact we're playing the team with the best defensive record in the league, we have to be at our best level."
The Glasgow head coach also called for the home fans to play a big part, with an extra stand being installed at Scotstoun and a full house expected.
"Our last game, against Munster , was a sell-out and the energy we get from the supporters is great," said Gregor.
"You can see the players really respond to it."