Centre Mark Bennett has recovered from injury (hamstring) to return to the squad.
Tight-head prop Jon Welsh (absent through a shoulder injury) also earns a recall, while Peter Horne could feature for the first time since the summer tour.
Scotland Head Coach, Vern Cotter, said: “We start with a very difficult game against France in Paris and we will prepare as best as possible for that game and adapt as the competition evolves.
"The players will want to characterise the traditional traits of the Scottish game; attacking with ferocity, destabilising the opposition and trying to play smart.
“Every time they pull on the jersey they will want to express themselves fully, so it’s with excitement that we look to the Six Nations, because we want to see how far we can compete, how well we can adapt, and how well we can equip ourselves in this very tough competition.
“I’m very confident that the players selected will underline the improvements we showed in the autumn as well as some others as the group continues to come together.
“We were all affected so positively by the support during the viagogo Autumn Tests, which really lifted the players and made them so proud to pull on the shirt and play here at BT Murrayfield.
“It’s a great challenge.”
FORWARDS: Hugh Blake (Edinburgh Rugby), Fraser Brown (Glasgow Warriors), Blair Cowan, Geoff Cross (both London Irish), David Denton, Alasdair Dickinson (Edinburgh Rugby), Jonny Gray (Glasgow Warriors), Richie Gray (Castres), Ross Ford (Edinburgh Rugby), Jim Hamilton (Saracens), Robert Harley, Euan Murray, Gordon Reid (all Glasgow Warriors), Alasdair Strokosch (Perpignan), Ben Toolis, Hamish Watson (both Edinburgh Rugby), Jon Welsh (Glasgow Warriors).
BACKS: Mark Bennett (Glasgow Warriors), Sam Hidalgo-Clyne (Edinburgh Rugby), Alex Dunbar, (Glasgow Warriors) Dougie Fife (Edinburgh Rugby), Stuart Hogg, Peter Horne (both Glasgow Warriors) Greig Laidlaw CAPTAIN (Gloucester), Sean Lamont, Sean Maitland, Henry Pyrgos, Finn Russell (all Glasgow Warriors), Matt Scott (Edinburgh Rugby), Tommy Seymour (Glasgow Warriors), Greig Tonks, Tim Visser (both Edinburgh Rugby).
Unavailable through injury: Adam Ashe (neck), Chris Fusaro (ankle), Grant Gilchrist (arm), Tyrone Holmes (face), Ruaridh Jackson (knee), Duncan Taylor (hamstring), Duncan Weir (arm)