Captain Greig Laidlaw will lead his men into his first Rugby World Cup outing at his club ground in Gloucester alongside stand-off Finn Russell.
Centres Matt Scott and Mark Bennett have been given the nod to get Scotland’s campaign underway in midfield, with full-back Stuart Hogg and wings Sean Lamont and Tommy Seymour completing the back division.
Edinburgh Rugby prop Alasdair Dickinson will also run out in familiar surroundings, with the former Gloucesterman (2007-11) selected to start alongside club-mates Ross Ford (hooker) and Willem Nel (prop).
Grant Gilchrist will partner Jonny Gray in the second-row, with Ryan Wilson, John Hardie and number 8 David Denton named as the starting loose forwards.
On the bench Ryan Grant has recovered from his ankle injury to join Fraser Brown and Jon Welsh as the front-row replacements, Richie Gray and the uncapped Josh Strauss deputise at lock and back-row, while Henry Pyrgos, Peter Horne and Sean Maitland provide cover across the backs.
Scotland
15 Stuart Hogg (Glasgow Warriors)
14 Tommy Seymour (Glasgow Warriors)
13 Mark Bennett (Glasgow Warriors)
12 Matt Scott (Edinburgh Rugby)
11 Sean Lamont (Glasgow Warriors)
10 Finn Russell (Glasgow Warriors)
9 Greig Laidlaw CAPTAIN (Gloucester)
1 Alasdair Dickinson (Edinburgh Rugby)
2 Ross Ford (Edinburgh Rugby)
3 Willem Nel (Edinburgh Rugby)
4 Grant Gilchrist (Edinburgh Rugby)
5 Jonny Gray (Glasgow Warriors)
6 Ryan Wilson (Glasgow Warriors)
7 John Hardie (unattached)
8 David Denton (Edinburgh Rugby)
Substitutes
16 Fraser Brown (Glasgow Warriors)
17 Ryan Grant (Glasgow Warriors)
18 Jon Welsh (Newcastle Falcons)
19 Richie Gray (Castres)
20 Josh Strauss (Glasgow Warriors)
21 Henry Pyrgos (Glasgow Warriors)
22 Peter Horne (Glasgow Warriors)
23 Sean Maitland (London Irish)