Greig Tonks takes over at full-back, with Lee Jones and Rory Hughes completing a new back three that boasts a total of 13 caps.
There is also a whole new front row with Gordon Reid, Fraser Brown and Zander Fagerson selected.
Jonny Gray comes into the second-row to partner Ben Toolis, while Hamish Watson returns at openside.
Duncan Taylor moves from number 15, where he played in the win over Italy in Singapore, to inside centre.
Scotland
15 Greig Tonks (London Irish)
14 Lee Jones (Glasgow Warriors)
13 Alex Dunbar (Glasgow Warriors)
12 Duncan Taylor (Saracens)
11 Rory Hughes (Glasgow Warriors)
10 Finn Russell (Glasgow Warriors)
9 Ali Price (Glasgow Warriors)
1 Gordon Reid (London Irish)
2 Fraser Brown (Glasgow Warriors)
3 Zander Fagerson (Glasgow Warriors)
4 Ben Toolis (Edinburgh Rugby)
5 Jonny Gray (Glasgow Warriors)
6 John Barclay (Scarlets) CAPTAIN
7 Hamish Watson (Edinburgh Rugby)
8 Ryan Wilson (Glasgow Warriors)
Substitutes
16 Ross Ford (Edinburgh Rugby)
17 Allan Dell (Edinburgh Rugby)
18 Willem Nel (Edinburgh Rugby)
19 Tim Swinson (Glasgow Warriors)
20 Josh Strauss (Sale Sharks)
21 Henry Pyrgos (Glasgow Warriors)
22 Ruaridh Jackson (Wasps)
23 Matt Scott (Gloucester)