Darge is one of six Warriors selected for Saturday afternoon's match, as Scotland look to bounce back from a disappointing defeat in Cardiff a fortnight ago.
Tight-head Zander Fagerson joins Darge in the starting pack, extending his run of consecutive matches in a Scotland shirt to nine.
Ali Price continues at scrum-half and is in line to win his 49th cap while Sione Tuipulotu is retained at inside centre, having made an impressive 67 metres from six carries in Cardiff last time out.
The replacements see George Turner continue in the number 16 jersey and Oli Kebble completes the Glasgow contingent in the matchday 23 having been added to the Scotland squad earlier this week.
Scotland team
15 Stuart Hogg - Exeter Chiefs (Captain)
14 Darcy Graham - Edinburgh Rugby
13 Chris Harris - Gloucester Rugby
12 Sione Tuipulotu - Glasgow Warriors
11 Duhan van der Merwe - Worcester Warriors
10 Finn Russell - Racing 92 (Vice-Captain)
9 Ali Price - Glasgow Warriors
1 Pierre Schoeman - Edinburgh Rugby
2 Stuart McInally - Edinburgh Rugby
3 Zander Fagerson - Glasgow Warriors
4 Sam Skinner - Exeter Chiefs
5 Grant Gilchrist - Edinburgh Rugby (Vice-Captain)
6 Rory Darge - Glasgow Warriors
7 Hamish Watson - Edinburgh Rugby
8 Magnus Bradbury - Edinburgh Rugby
Substitutes
16 George Turner - Glasgow Warriors
17 Oli Kebble - Glasgow Warriors
18 WP Nel - Edinburgh Rugby
19 Jamie Hodgson - Edinburgh Rugby
20 Nick Haining - Edinburgh Rugby
21 Ben White - London Irish
22 Blair Kinghorn - Edinburgh Rugby
23 Mark Bennett - Edinburgh Rugby