Captain Jamie Ritchie leads his country in their Pool B clash with defending champions South Africa at Marseille's Stade Velodrome, the blindside flanker joined in the back row by openside Rory Darge and Jack Dempsey at number 8.
Richie Gray and Grant Gilchrist, both of whom will be appearing at a third Rugby World Cup, combine in the second row.
In the back division, Finn Russell - also primed for a third such tournament - links up with scrum-half Ben White, with centres Sione Tuipulotu and Huw Jones continuing their partnership for the Springbok showdown.
Prolific wingers Duhan van der Merwe and Darcy Graham are joined in the back three by full back Blair Kinghorn.
Scotland's forward replacements comprise hooker Dave Cherry, props Jamie Bhatti and WP Nel (the latter another set to appear at a trio of Rugby World Cups), as well as the versatile Scott Cummings and Matt Fagerson.
Injury update: Stuart McInally has travelled out to France as injury cover for Ewan Ashman, who is recovering from an injury picked up in training this week which ruled him out of the match against South Africa. McInally has not joined the 33-player squad.
15 Blair Kinghorn (Edinburgh Rugby) 46 caps
1.Pierre Schoeman (Edinburgh Rugby) 23 caps
2 George Turner (Glasgow Warriors) 37 caps
3 Zander Fagerson (Glasgow Warriors) 59 caps
4 Richie Gray (Glasgow Warriors) 75 caps
5 Grant Gilchrist (Edinburgh Rugby) - Vice-captain - 65 caps
6 Jamie Ritchie (Edinburgh Rugby) - Captain - 43 caps
7 Rory Darge (Glasgow Warriors) 11 caps
8 Jack Dempsey (Glasgow Warriors) 12 caps
16 Dave Cherry (Edinburgh Rugby) 10 caps
17 Jamie Bhatti (Glasgow Warriors) 32 caps
18 WP Nel (Edinburgh Rugby) 57 caps
19 Scott Cummings (Glasgow Warriors) 29 caps
20 Matt Fagerson (Glasgow Warriors) 36 caps
21 Ali Price (Glasgow Warriors) 63 caps
22 Cameron Redpath (Bath Rugby) 7 caps
23 Ollie Smith (Glasgow Warriors) 6 caps