George Horne is set to become the latest Warriors centurion as the scrum-half returns from Scotland duty to the squad for Sunday afternoon's match at Scotstoun (ko 4.00pm).
The Howe of Fife product is selected on a strong Glasgow bench. When he's called into action Horne will follow in the footsteps of elder brother Pete in reaching 100 appearances, becoming just the second pair of brothers - following Alan and Gordon Bulloch - to join the ranks of Glasgow Warriors centurions.
Summer signing Henco Venter will also celebrate a landmark milestone, as the South African back-rower makes his competitive debut for the club in the back-row.
In total, seven Scotland internationals return to club action this weekend, with Zander Fagerson starting at tight-head alongside Angus Fraser - making his first competitive appearance at Scotstoun - and Oli Kebble in the front-row.
Greg Peterson makes his second Scotstoun debut after returning to the club on a short-term deal, the USA international packing down alongside Scott Cummings to re-form a partnership last seen in the 2018/19 campaign.
Rory Darge comes straight back into the starting XV to line up at openside, joining debutant Venter and blindside Gregor Brown in the back-row trio.
Jamie Dobie makes his third successive start at scrum-half after captaining the Warriors in both of the club's pre-season fixtures, whilst Tom Jordan moves from the midfield to the number 10 jersey for the season opener.
An all-international midfield combination sees Stafford McDowall start at inside centre, with fellow Scotland cap Huw Jones coming into the team to start outside him in the 13 shirt.
Kyle Steyn captains the side from the wing on his return to Glasgow colours, as he joins Josh McKay - on his first competitive outing since March - and Sebastian Cancelliere in the back-three.
The club's most recent Scotland international can be found amongst the replacements, as Johnny Matthews joins Nathan McBeth and Lucio Sordoni as the front-row cover for Sunday's clash.
Alex Samuel wears the number 19 shirt after impressing in both of the club's pre-season fixtures, with Ally Miller and Tom Gordon joining the second-rower in a six-two split of forwards and backs.
Centurion-in-waiting Horne covers the backs alongside the experienced figure of Duncan Weir, the fly-half set to make his 134th appearance in the colours of his hometown club.
Speaking following selection, Head Coach Franco Smith told glasgowwarriors.org: "Everyone cannot wait for the start of the new season.
"It's a great feeling to be able to kick off the season at home, and we're looking forward to running out in front of the Warrior Nation once more - it's been a long time since we played a competitive match at Scotstoun, and the boys are really excited to get going.
"Even without some of their stars, Leinster have been a formidable force in the URC in recent seasons, and we look forward to what will be a strong test this Sunday."
15 Josh McKay
14 Sebastian Cancelliere
13 Huw Jones
12 Stafford McDowall
11 Kyle Steyn (Captain)
10 Tom Jordan
9 Jamie Dobie
1 Oli Kebble
2 Angus Fraser
3 Zander Fagerson
4 Greg Peterson
5 Scott Cummings
6 Gregor Brown
7 Rory Darge
8 Henco Venter
Substitutes
16 Johnny Matthews
17 Nathan McBeth
18 Lucio Sordoni
19 Alex Samuel
20 Ally Miller
21 Tom Gordon
22 George Horne
23 Duncan Weir
Unavailable for selection: Fraser Brown (knee), Facundo Cordero (ankle), Euan Ferrie (ankle), JP du Preez (knee), Murphy Walker (calf)