Scotland's slow start left them with too much to do after England scored tries through Craig Wright, Sean Kerr - who also kicked two penalties - and Finn Carnduff.
Euan McVie responded with a try for the hosts but Nathan Michelow ended any hope of a Scottish comeback with a bonus-point score.
Scotland kept playing and Freddy Douglas capped off an impressive performance with a try off the back of a maul and Geordie Gwynn finished off another score in the corner.
Next up, Scotland travel to Italy still chasing a first win of the championship.