The Glasgow Warrior, who made his international debut in 2018, is named at No.8 and will anchor a back row containing openside flanker Rory Darge and Jamie Ritchie, who has been named on the blindside.
The rest of Scotland's starting pack who faced South Africa two weeks ago is reinstated, with Grant Gilchrist and Scott Cummings once more forming the second row.
And up front, Ewan Ashman returns at hooker, either side of loosehead prop Pierre Schoeman and Zander Fagerson at tighthead.
Captain Sione Tuipulotu links up with Huw Jones to resume their familiar centre partnership, with half-backs Ben White and Finn Russell - who needs three points to reach 400 for his country - also returning to the starting XV.
In the back three, Darcy Graham - the sole starting survivor from last weekend's 59-21 success against Portugal - lines up with fellow winger Duhan van der Merwe, as Blair Kinghorn is selected at full-back.
Hooker Dylan Richardson and props Rory Sutherland and Will Hurd provide front row cover, with the versatile Alex Craig and Josh Bayliss also named as forward replacements.
Scotland's final 23 of The Famous Grouse Nations Series is completed by backs George Horne, Tom Jordan and Kyle Rowe.
Scotland
15 Blair Kinghorn - Toulouse (54)
14 Darcy Graham - Edinburgh Rugby (41)
13 Huw Jones - Glasgow Warriors (52)
12 Sione Tuipulotu - Glasgow Warriors (29) CAPTAIN
11 Duhan van der Merwe - Edinburgh Rugby (43)
10 Finn Russell - Bath Rugby (81) VICE-CAPTAIN
9 Ben White - Toulon (23)
1 Pierre Schoeman - Edinburgh Rugby (36)
2 Ewan Ashman - Edinburgh Rugby (21)
3 Zander Fagerson - Glasgow Warriors (69)
4 Grant Gilchrist - Edinburgh Rugby (74)
5 Scott Cummings - Glasgow Warriors (41)
6 Jamie Ritchie - Edinburgh Rugby (53)
7 Rory Darge - Glasgow Warriors (24) VICE-CAPTAIN
8 Matt Fagerson - Glasgow Warriors (49)
Substitutes
16 Dylan Richardson - The Sharks (5)
17 Rory Sutherland - Glasgow Warriors (36)
18 Will Hurd - Leicester Tigers (3)
19 Alex Craig - Scarlets (5)
20 Josh Bayliss - Bath Rugby (9)
21 George Horne - Glasgow Warriors (33)
22 Tom Jordan - Glasgow Warriors (3)
23 Kyle Rowe - Glasgow Warriors (9)