He will undergo surgery this week and is expected to return to action before the end of the season.
In Scotland skipper Tuipulotu's absence, Rory Darge will serve as co-captain alongside Finn
Russell, the combination having led the Scots during the 2024 Guinness Six Nations.
Scott Cummings sustained an arm fracture during Glasgow Warriors match against Harlequins at the weekend. He is also likely to miss the tournament, and will undergo further review to determine when he will be fit to return.