Zander Fagerson starts again being joined by Sutherland as he rotates off the bench and into the starting line-up.
The back-row is an all Glasgow unit as Dempsey moves in to start in the back row with Matt Fagerson and Rory Darge. Rory Darge is also named as Co-Captain.
Jordan comes in at inside-centre to join hat-trick hero Huw Jones in the centres, while Stafford McDowall moves to the bench.
Gregor Brown will once again be looking to make an impact off the bench as he provides second row cover.
Jamie Dobie will be looking to make his first Six Nations appearance of the year should he come off the bench.
Scotland
15 Blair Kinghorn - Toulouse (56)
14 Darcy Graham - Edinburgh Rugby (43)
13 Huw Jones - Glasgow Warriors (54)
12 Tom Jordan - Glasgow Warriors (4)
11 Duhan van der Merwe - Edinburgh Rugby (45)
10 Finn Russell - Bath Rugby (83) CO-CAPTAIN
9 Ben White - Toulon (25)
1 Rory Sutherland - Glasgow Warriors (38)
2 Dave Cherry - Edinburgh Rugby (12)
3 Zander Fagerson - Glasgow Warriors (71)
4 Jonny Gray - Bordeaux Begles (78)
5 Grant Gilchrist - Edinburgh Rugby (76)
6 Matt Fagerson - Glasgow Warriors (51)
7 Rory Darge - Glasgow Warriors (26) CO-CAPTAIN
8 Jack Dempsey - Glasgow Warriors (23)
Substitutes
16 Ewan Ashman - Edinburgh Rugby (23)
17 Pierre Schoeman - Edinburgh Rugby (38)
18 Will Hurd - Leicester Tigers (5)
19 Sam Skinner - Edinburgh Rugby (35)
20 Gregor Brown - Glasgow Warriors (5)
21 Jamie Ritchie - Edinburgh Rugby (55)
22 Jamie Dobie - Glasgow Warriors (9)
23 Stafford McDowall - Glasgow Warriors (9)