Brown has featured in all four of Scotland's fixtures in the tournament to date and is one of nine Glasgow Warriors selected in Gregor Townsend's matchday 23.
Zander Fagerson makes his sixth consecutive start in the front-row, the tight-head the only Glasgow Warrior to have started in Scotland's most-recent win in Paris, having anchored the scrum in the 27-23 triumph over Les Bleus in 2021.
Rory Darge starts as co-captain on the openside flank, having made more tackles than any other Scottish player during the Guinness Six Nations to date.
Matt Fagerson comes in to start in place of Jack Dempsey at number eight, following a performance off the bench last weekend that saw him record 13 tackles - the joint most of any Scottish player - and beat three defenders with ball in hand.
Tom Jordan continues at inside-centre, following a display against Wales that saw him register his first two tries in Scotland colours.
Huw Jones lines up outside him in the number 13 jersey, with only Louis Bielle-Biarrey ahead of him in this season's try-scoring charts.
Rory Sutherland is one of three further Warriors awaiting their opportunity from the bench.
Jamie Dobie returns to the matchday 23 after being rested against Wales last week and covers the back-three in a six-two split of forwards and backs.
Stafford McDowall completes the Glasgow contingent, with the centre set to make his fifth consecutive appearance for his country.
Scotland
15 Blair Kinghorn - Toulouse (59)
14 Darcy Graham - Edinburgh Rugby (45)
13 Huw Jones - Glasgow Warriors (57)
12 Tom Jordan - Glasgow Warriors (7)
11 Duhan van der Merwe - Edinburgh Rugby (48)
10 Finn Russell - Co-Captain - Bath Rugby (86)
9 Ben White - Toulon (28)
1 Pierre Schoeman - Edinburgh Rugby (41)
2 Dave Cherry - Edinburgh Rugby (15)
3 Zander Fagerson - Glasgow Warriors (74)
4 Gregor Brown - Glasgow Warriors (8)
5 Grant Gilchrist - Edinburgh Rugby (79)
6 Jamie Ritchie - Edinburgh Rugby (58)
7 Rory Darge - Co-Captain - Glasgow Warriors (29)
8 Matt Fagerson - Glasgow Warriors (54)
Substitutes
16 Ewan Ashman - Edinburgh Rugby (26)
17 Rory Sutherland - Glasgow Warriors (40)
18 Will Hurd - Leicester Tigers (8)
19 Jonny Gray - Bordeaux Begles (81)
20 Marshall Sykes - Edinburgh Rugby (1 cap)
21 Ben Muncaster - Edinburgh Rugby (1)
22 Jamie Dobie - Glasgow Warriors (11)
23 Stafford McDowall - Glasgow Warriors (12)