After an indifferent run-in to the regular season Glasgow won 27-10 at home to Stormers at the same stage last year before securing away victories over Munster and Bulls to claim the URC trophy.
Warriors lost the final three games of the URC campaign to drop from second to fourth and are preparing to take on Stormers in the URC quarter-final at Scotstoun on Friday night.
"We'd done a lot of losing big games in the past and that kind of probably gave us the experience to work out what was needed to be done to win it last year," said Horne.
"But you can't just expect that to happen again, we've got to make it happen. We've got a good, experienced team now. We've been there and done it, but it's going to have to be done again if we want to keep going further in this competition.
"We can learn from it, obviously playing the same opposition, but it means nothing in terms of going into this year," Horne said of the upcoming visit from the South Africans. "We've still got to put out a performance this weekend.
"We can't just rest on the laurels of what we did last year. We'll use the experience of winning those tight games, but we know we've got to turn up on Friday if we're going to do it again."