The fixture - which serves as the first outing for the squad ahead of the 2025 tour to Australia - will mark the first meeting between the Lions and Argentina in 20 years, the two squads having played out a 25-25 draw in Cardiff ahead of the 2005 tour.
Tuipulotu's selection sees the centre line up in the number 13 jersey while Cummings is named amongst the replacements.
The Lions kick-off their campaign at the Aviva Stadium this Friday, with kick-off scheduled for 8.00pm - supporters can watch the match live on Sky Sports.
British & Irish Lions
15 Marcus Smith
14 Tommy Freeman
13 Sione Tuipulotu
12 Bundee Aki
11 Duhan van der Merwe
10 Fin Smith
9 Alex Mitchell
1 Ellis Genge
2 Luke Cowan-Dickie
3 Finlay Bealham
4 Maro Itoje (Captain)
5 Tadhg Beirne
6 Tom Curry
7 Jac Morgan
8 Ben Earl
Substitutes
16 Ronan Kelleher
17 Pierre Schoeman
18 Tadhg Furlong
19 Scott Cummings
20 Henry Pollock
21 Tomos Williams
22 Elliot Daly
23 Mack Hansen