Kenny Sinclair has not recovered from a head knock he took in training on Tuesday, and Graeme Morrison is the latest Glasgow player to go down with flu.
Mark McMillan, the Scotland Under-21 scrum half from Stirling County, takes over from Sinclair. It will be the Mark's first competitive start for Glasgow.
Morrison's withdrawal has meant a threequarter-line shuffle. Gareth Maclure has switched from left wing to Morrison's place at outside centre, Sean Lamont has moved from right to left wing, and Jon Steel returns on the right.
Richie McKnight, Glasgow Hawks' scrum half, and Rory McKay flew south earlier today to fill the vacancies on the replacements' bench. McKay had originally been left out because of flu earlier in the week, though he has now fully recovered.