Andy will be facing friends, former teammates and, in Adam Jones, his son's godfather - and he's determined not to give them bragging rights.
"I have a lot of very close friends who still play for the Ospreys and my young lad Alfie is Adam's godson.
"However, all emotions and memories will go out the window when I run on to the pitch because all I am interested in is helping Glasgow keep up their winning run," said Andy in the Daily Record.
"They have been on the phone winding me up, tongue in cheek," Andy said in The Times. "But I know that the fact I am playing gives them an extra reason to want to win because I am the world's worst winner and if we do come out on top, I won't let them forget it."
Andy played for Neath and then the Ospreys before moving to Glasgow. "I don't think they have a great record here," he added. "When I came with them, they have lost and drawn games and even when they have won, it has been close."