The Warriors play Edinburgh at Firhill on Friday afternoon and the Glasgow coach is looking for his players to even things up.
"We have not become a bad team over- night and from that point of view it is important that we don't have a knee-jerk reaction," Sean told the Evening Times.
"The players know they let themselves down at Murrayfield and in a match watched by the Scotland selectors I can't think of one of our players who got the better of his opponent.
"But it is gone now and the positive thing is that we have the chance to even things up straight away at Firhill on Friday.
"Our pride as professionals is at stake and we must pull out all the stops to get this right.
"But I have to say that this is probably the most challenging week as a coach ahead of me after what was my worst defeat as a coach.
"We were nowhere near physical enough at the contact and breakdown and that has to be sorted for Friday. I felt the Edinburgh lads just had more desire than we did.
"I think we went out there thinking we were going to get the win, but not ready to do the work required to get it.
"We were not helped by some of the officiating, but what we have to do at Firhill is go out there and take the match out of the hands of the referee. There is a lot on the line this Friday."