The Warriors kicked off their Pool Six challenge with a 21-13 success over Newport Gwent Dragons last weekend, winning their opening Heineken fixture for the first time since the 1997-98 season.
And Sean, who has named an unchanged starting line-up for the trip to Wycombe, hopes his side can kick on from that win.
"We need to look at this game and go 'what an opportunity'," said Sean.
"This is the first time for so long that Glasgow have won their first-up Heineken game, so for us, this represents something special, maybe we can make a bit of history."
Wasps came close to causing a huge upset in their opening fixture at defending champions Toulouse, and Sean knows his side will face a stern test against the two-time European kings.
"Going down there is going to be incredibly difficult," he added. "Wasps are a quality team with a lot of pedigree behind them in the Heineken Cup.
"They have quality individuals with a lot of belief and are a very physical team."
14 DTH van der Merwe
13 Max Evans
12 Graeme Morrison
11 Federico Aramburu
10 Ruaridh Jackson
9 Colin Gregor
1 Jon Welsh
2 Fergus Thomson
3 Moray Low
4 Tom Ryder
5 Richie Gray
6 Robert Harley
7 John Barclay CAPTAIN
8 Richie Vernon
Substitutes: 16 Dougie Hall, 17 Ryan Grant, 18 Ed Kalman, 19 Ryan Wilson, 20 Calum Forrester, 21 Henry Pyrgos, 22 Duncan Weir, 23 Rob Dewey