Although the Warriors go into the second leg 12 points ahead following their 30-18 win at Firhill on Monday, they do so having made three enforced changes to the match-day squad.
Peter Murchie will continue at inside centre having replaced the injured Graeme Morrison in the early stages of Monday’s match. Peter Horne will take Murchie’s place on the bench.
Meanwhile, following replacement flanker Chris Fusaro’s one week suspension for the red card shown in the dying minutes of the first leg, Ryan Wilson will now seek to get his first taste of the age-old derby from the subs bench.
Heading to a place where Edinburgh have lost only two of their opening seven games, Warriors head coach Sean Lineen said: “We need to improve on last week if we are to be in with a chance of winning at Murrayfield.
“Edinburgh will be hurting after the first leg - we know because we’ve been there before - and they will come out firing on all cylinders.
“These games are very special, and there are Magners League points at stake as well, so that is also in the back of our minds.”
14 Hefin O'Hare
13 Max Evans
12 Peter Murchie
11 DTH van der Merwe
10 Ruaridh Jackson
9 Colin Gregor
1 Jon Welsh
2 Fergus Thomson
3 Moray Low
4 Richie Gray
5 Alastair Kellock CAPTAIN
6 Robert Harley
7 John Barclay
8 Richie Vernon
Substitutes
16 Dougie Hall, 17 Ryan Grant, 18 Kevin Tkachuk, 19 Aly Muldowney, 20 Ryan Wilson, 21 Henry Pyrgos, 22 Peter Horne, 23 Federico Aramburu