The Warriors fly-half will win his fourth cap on Sunday, replacing Dan Parks, who drops to the bench, as one of seven changes to the Scotland side which lost 24-6 in an error-strewn display against Wales.
Full-back Chris Paterson, centre Sean Lamont, scrum-half Mike Blair, prop Moray Low, lock Richie Gray and number eight Johnnie Beattie also come in.
Rory Lawson, Nathan Hines and Richie Vernon all drop to the bench, while tight-head prop Euan Murray is unavailable as he refuses to play on Sundays because of religious reasons.
Northampton centre Joe Ansbro and full-back Hugo Southwell, who started the Wales game, are injured, as is Toulon full-back Rory Lamont.
A positional switch sees Nick De Luca move from inside centre to the number 13 shirt. On the bench, Geoff Cross and Simon Danielli are involved in a Scotland 22 for the first time this year.
Scotland
15 Chris Paterson (Edinburgh)
14 Nikki Walker (Ospreys)
13 Nick De Luca (Edinburgh)
12 Sean Lamont (Scarlets)
11 Max Evans (Glasgow Warriors)
10 Ruaridh Jackson (Glasgow Warriors)
9 Mike Blair (Edinburgh)
1 Allan Jacobsen (Edinburgh)
2 Ross Ford (Edinburgh)
3 Moray Low (Glasgow Warriors)
4 Richie Gray (Glasgow Warriors)
5 Alastair Kellock (Glasgow Warriors) CAPTAIN
6 Kelly Brown (Saracens)
8 Johnnie Beattie (Glasgow Warriors)
7 John Barclay (Glasgow Warriors)
Substitutes
16 Scott Lawson (Gloucester)
17 Geoff Cross (Edinburgh)
18 Nathan Hines (Leinster)
19 Richie Vernon (Glasgow Warriors)
20 Rory Lawson (Gloucester)
21 Dan Parks (Cardiff Blues)
22 Simon Danielli (Ulster)
Referee: Nigel Owens (Wales)
Assistant referees: Andrew Small (England) and Pascal Gauzere (France)
TMO: Graham Hughes (England)