In an incredibly tight finish seven clubs will fight it out for two British & Irish Cup places, all seven of whom will also be trying to avoid a relegation play-off.
Ayr and Gala will finish in first and second place respectively and securing their places in the cross-border tournament next season, while Boroughmuir will definitely drop into the National League for 2013/14.
Heriot’s, Stirling County, Edinburgh Accies, Melrose, Aberdeen Grammar, Dundee HSFP and Currie have five points separating them between third (41 points) and ninth place (36 points).
The team who finishes in ninth will go into a play-off with the runner-up of the National League, which will be decided this weekend too, between Glasgow Hawks and Hawick.
All seven teams are also in the mix for the last two British & Irish Cup places next season.
The fixtures this weekend are (ko 3.00pm):
Gala v Melrose
Boroughmuir v Edinburgh Accies
Currie v Heriot’s
Aberdeen Grammar v Ayr
Dundee HSFP v Stirling County Match postponed due to waterlogged pitch
Glasgow's Mark Bennett and Byron McGuigan start for Stirling County with EDP back row Adam Ashe among the County replacements.
EDP duo Fraser Thomson and Bruce Dick start for Melrose while stand-off Scott Wight plays for Aberdeen against Ayr.
The Premiership champions include Nick Campbell, Murray McConnell and George Hunter.