The Glasgow duo replace their injured teammates Finn Russell and Jonny Gray who are both ruled out.
Finn has been ruled out of the fixture with concussion, despite his continued progression through the graduated return-to-play protocol.
Jonny is ruled out due to a pectoral tear he picked up in last weekend's win over France.
Eleven Warriors are in the matchday squad with Robert Harley and Henry Pyrgos called up to the bench.
Scotland
15 Stuart Hogg (Glasgow Warriors)
14 Tommy Seymour (Glasgow Warriors)
13 Duncan Taylor (Saracens)
12 Alex Dunbar (Glasgow Warriors)
11 Tim Visser (Harlequins)
10 Duncan Weir (Glasgow Warriors)
9 Greig Laidlaw CAPTAIN (Gloucester)
1 Alasdair Dickinson (Edinburgh Rugby)
2 Ross Ford (Edinburgh Rugby)
3 Willem Nel (Edinburgh Rugby)
4 Richie Gray (Castres)
5 Tim Swinson (Glasgow Warriors)
6 John Barclay (Scarlets)
7 John Hardie (Edinburgh Rugby)
8 Ryan Wilson (Glasgow Warriors)
Substitutes
16 Stuart McInally (Edinburgh Rugby)
17 Rory Sutherland (Edinburgh Rugby)
18 Moray Low (Exeter Chiefs)
19 Robert Harley (Glasgow Warriors)
20 Josh Strauss (Glasgow Warriors)
21 Henry Pyrgos (Glasgow Warriors)
22 Pete Horne (Glasgow Warriors)
23 Sean Lamont (Glasgow Warriors)