Uruguay come into the game on a back of a 79-5 hammering by Argentina last weekend but Glasgow lock Scott Cummings still expects "a pretty tough battle" at El Estadio Charrua.
The Scots are looking for their fourth consecutive win to end their Americas Tour.
But, at 17th in the world, 11 places below the Scots, Uruguay are their highest-ranked opponents yet.
"They've been playing really well recently, Uruguay, although obviously they had a wee blip at the weekend," Cummings said. "They are really physical up front, they've got some good backs and we're expecting a pretty tough battle.
"We still believe, if we play our game, we'll do well. But if we get caught up in the moment and go off-script then they'll make it a tough day for us."
While some of Scotland's top players were rested for the tour, Cummings was happy to be involved - despite it coming after Glasgow Warriors' long journey to United Rugby Championship final victory.
"Obviously it's been a long season and especially long for us Glasgow guys and we are happy how it ended and wouldn't have it any other way," he added.
"A lot of the boys haven't had to play back-to-back games on this tour, so everyone is feeling pretty good and pretty fresh. We are still raring to go.
"Obviously it's the end of the season, so there's going to be sore bodies, but we are still excited for these games and hopefully we can sign off in a good way."