Junior Bulumakau will make his competitive debut after joining the club last month and scored against both Clermont and Canada during pre-season.
He comes into the team for the injured Rory Hughes, and will play on the right wing with Lee Jones moving to the opposite side.
Glenn Bryce once again starts at full-back, with Peter Murchie and Fraser Lyle forming the centre partnership.
Rory Clegg and Mike Blair make their first starts for the club at stand-off and scrum-half respectively.
After coming on as a second-half replacement last Saturday, Alex Allan starts the game at loose-head, Pat MacArthur returns from illness at hooker and Mike Cusack is once again named at tight-head.
Scott Cummings continues in the engine room and partners Kieran Low, who makes his first start for the club after featuring off the bench in the defeat to Scarlets.
Robert Harley moves to blindside flanker in place of Josh Strauss, with Adam Ashe and Chris Fusaro continuing at Number 8 and openside respectively.
Backrower Hugh Blake has been named amongst the replacements and could make his first appearance in a Warriors shirt tomorrow night.
Glasgow Warriors head coach Gregor Townsend said: "We were disappointed to lose our opening game against the Scarlets, but the effort in the second-half last week was really encouraging and much more what we expect from our players.
"For those selected to play Connacht, it's an opportunity to put what we've learned last week and what we've been working on in training this week into a much-improved performance.
"Connacht are a very good side who have a strong set-piece and come into this game off the back of a win against the Dragons last weekend. Our two opening fixtures were always going to be tough and we know we'll have to perform very well to win tomorrow night.
"Our supporters created a fantastic atmosphere last Saturday and we're looking forward to playing in front of them once again."
15 Glenn Bryce
14 Junior Bulumakau
13 Peter Murchie (Captain)
12 Fraser Lyle
11 Lee Jones
10 Rory Clegg
9 Mike Blair
1 Alex Allan
2 Pat MacArthur
3 Michael Cusack
4 Scott Cummings
5 Kieran Low
6 Robert Harley
7 Chris Fusaro
8 Adam Ashe
Substitutes
16 Kevin Bryce
17 Jerry Yanuyanutawa
18 Zander Fagerson
19 James Eddie
20 Tyrone Holmes
21 Hugh Blake
22 Grayson Hart
23 Scott Wight
Not available due to injury: Alex Dunbar (knee), Rory Hughes (shoulder) and Sam Johnson (shoulder)
Tickets for the GUINNESS PRO12 encounter at Scotstoun are still available HERE and from the ticket office on 0844 800 3490 (Monday to Friday, 9am-5pm).